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1. First and foremost, to me, it's the situations that these game play elements are presented in, and a lot of that has to do with the PS3's processing prowess. The game is cinematic, but rather than having you put the controller down and force 30 minutes long cutscenes down your throat, Uncharted 2 actually lets you in control of the game's many memorable cinematic sequences. There's recently talk about an Uncharted movie in the works. Screw that. This game is a better movie than any movie about this game is going to be.
2. The cast of characters in Uncharted 2, especially the protagonist Nathan Drake himself, is among the most likeable fictional characters I can think of. The interactions between the characters and Drake's frequent talking to himself moments are as believable as you and me. The writing for this game is so brilliant and witty that it often left me grinning as I play. Something that doesn't happen too often.
3. Drake is no Hero figure. He's like John Mclane, but a decidedly more likeable one. Throughout the game, the odds are almost always stacked against him, and seeing him go through all those impossible odds by the skin of his teeth is some of the most satisfyingly breathtaking moments in recent entertainment history.
If I have to name some issues, the climbing animations can look a little janky at time, and I didn't like how the game becomes unnecessarily hard towards the end, but I hated dying so much only because I was so eager to know what's next for Nathan Drake. With Uncharted 2, Naugthy Dog has created a true masterpiece of a video game.